Research

MYC
Myc is a gene that regulates the expression of other genes, with important roles in a number of processes including cell death. Myc mutations are very common—over half of human cancers—and understanding its role in tumour cells is a major area of investigation.

STATINS
Drugs that are normally used to control cholesterol can also trigger tumour cells to self-destruct. Understanding the mechanisms of these drugs could lead to a new tool in the arsenal against cancer—one that is already approved for use in humans, fast-tracking its use in patients.
Publications
View and keep up to date on our most recent publications.
Statins as Anticancer Agents in the Era of Precision Medicine
Authors: Joseph Longo, Jenna E. van Leeuwen, Mohamad Elbaz, Emily Branchard, Linda Z. Penn Read MoreComputational pharmacogenomics screen identifies synergistic statin-compound combinations as anti-breast cancer therapies
Authors: Jenna van Leeuwen, Wail Ba-Alawi, Emily Branchard, Joseph Longo, Jennifer Silvester, David W. Cescon, Benjamin Haibe-Kains, Linda Z. Penn, Deena M.A. Gendoo Read MoreCyclic AMP‐hydrolyzing phosphodiesterase inhibitors potentiate statin‐induced cancer cell death
Longo J, Pandyra AA, Stachura P, Minden MD, Schimmer AD, Penn LZ. Read MoreLinda Penn
Led by Linda Penn, PhD, Senior Scientist at Princess Margaret and Tier 1 Canada Research Chair, the Penn Lab is composed of talented, hard-working students, post-doctoral fellows, and staff working together to understand cancer and develop new treatments. Click below to learn more about the people working in the lab and our alumni members.
People
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Lab News
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