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MYC

Myc is a gene that regulates the expression of other genes, with important roles in a number of processes including cell death. Myc mutations are very common—over half of human cancers—and understanding its role in tumour cells is a major area of investigation.

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STATINS

Drugs that are normally used to control cholesterol can also trigger tumour cells to self-destruct. Understanding the mechanisms of these drugs could lead to a new tool in the arsenal against cancer—one that is already approved for use in humans, fast-tracking its use in patients.

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Publications

View and keep up to date on our most recent publications.

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Statin
MYC

Sterol-like drugs potentiate statin-triggered prostate cancer cell death by inhibiting SREBP2 nuclear translocation
Authors: Dos Santos, D. Z., Elbaz, M., Branchard, E., Schormann, W., Brown, C. E., Meek, A. R., Njar, V. C. O., Hamilton, R. J., Reed, M. A., Andrews, D. W., & Penn, L. Z Read More

Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality
Authors: Lin, P., Lourenco, C., Cruickshank, J., Palomero, L., van Leeuwen, J. E., Tong, A. H. Y., Chan, K., El Ghamrasni, S., Pujana, M. A., Cescon, D. W., Moffat, J., & Penn, L. Z. Read More

Computational pharmacogenomic screen identifies drugs that potentiate the anti-breast cancer activity of statins
Authors: van Leeuwen J. E., Ba-Alawi W., Branchard E., Cruickshank J., Schormann W., Longo J., Silvester J., Gross P.L., Andrews D.W., Cescon D.W., Haibe-Kains B., Penn L.Z., Gendoo D. M. A. Read More

The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase
Authors: Wei Y., Redel C., Ahlner A., Lemak A., Johansson-Akhe I., Houliston S., Kenney T.M.G., Tamachi A., Morad V., Duan S., Andrews D.W., Wallner B., Sunnerhagen M., Arrowsmith C.H., Penn L.Z. Read More

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Linda Penn

Led by Linda Penn, PhD, Senior Scientist at Princess Margaret and Tier 1 Canada Research Chair, the Penn Lab is composed of talented, hard-working students, post-doctoral fellows, and staff working together to understand cancer and develop new treatments. Click below to learn more about the people working in the lab and our alumni members.